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Method for identifying a hedgehog-mediated phophorylation state dependent transcription factor
Method for identifying a hedgehog-mediated phophorylation state dependent transcription factor
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机译:识别刺猬介导的磷酸化状态依赖性转录因子的方法
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摘要
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
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