首页>
外国专利>
2-hydroxy-3amp;mdash;(4-hydroxy-3-sulfonamidophenyl)amp;mdash;propylamines useful as beta 3 adrenergic agonists
2-hydroxy-3amp;mdash;(4-hydroxy-3-sulfonamidophenyl)amp;mdash;propylamines useful as beta 3 adrenergic agonists
展开▼
机译：可用作β3肾上腺素能激动剂的2-羟基3-（4-羟基-3-磺酰胺基）丙胺
展开▼
页面导航
摘要
著录项
相似文献
摘要
Compounds are provided having the formula ;including pharmaceutically acceptable salts thereof, wherein;R1 is lower alkyl, aryl or arylalkyl;;A is hydrogen or ;B is hydrogen, alkyl, alkenyl, or ;but when A is hydrogen, B may only be ;R2, R2′, R2″, R3 R3′ and R3″ are as defined herein;;m is 0−3. These compounds possess activity at the beta 3 adrenergic receptor in mammals and are useful in the treatment of diabetes, obesity, depression, achalasia and intestinal hypermotility disorders.
展开▼
机译：提供的化合物的化学式为 ;包括其药学上可接受的盐，其中; R 1 是低级烷基，芳基或芳基烷基;; A是氢或<化学id =“ CHEM-US-00002”> <图像alt =“嵌入式图像” file =“ US06436914-20020820-C00002.GIF” he =“ 58.5711” id =“ EMI- C00002“ imgContent =” undefined“ imgFormat =” GIF“ wi =” 47.03265“ /> ; B是氢，烷基，烯基或<化学ID =“ CHEM-US-00003”> <图像alt =“嵌入式图像” file =“ US06436914-20020820-C00003.GIF” he =“ 42.49665” id =“ EMI- C00003“ imgContent =” undefined“ imgFormat =” GIF“ wi =” 60.4989“ /> ;但是当A是氢时，B只能是 <图像alt =”嵌入式图像“ file =” US06436914-20020820-C00004.GIF“ he =” 42.2415“ id =” EMI-C00004“ imgContent =” undefined“ imgFormat =” GIF“ wi =” 60.98085“ /> ExternalFileRef externalType =“化学分子文件” file =“ US06436914-20020820-C00004.MOL “ id =” CHEMMOL-00004“ /> ; R 2 ，R 2＆prime; ，R 2＆Prime; ，R 3 R 3＆prime; 和R 3＆Prime; 如本文中所定义;; m为0减去; 3。这些化合物在哺乳动物中对β3肾上腺素能受体具有活性，可用于治疗糖尿病，肥胖症，抑郁症，门失弛缓症和肠动力亢进症。
展开▼
