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Vectors, cells, and methods for the production of deleterious adenoviral, herpes viral and adeno-associated viral vectors
Vectors, cells, and methods for the production of deleterious adenoviral, herpes viral and adeno-associated viral vectors
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机译:产生有害腺病毒,疱疹病毒和腺相关病毒载体的载体,细胞和方法
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摘要
The present invention provides a method of in vitro propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i.e., a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e.g., a mammalian, host-production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.
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