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Methods of spray-drying a drug and a hydrophobic amino acid
Methods of spray-drying a drug and a hydrophobic amino acid
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机译:喷雾干燥药物和疏水性氨基酸的方法
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摘要
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (% w) water, usually below about 5% w and preferably less than about 3% w; a particle size of about 1.0-5.0 m mass median diameter (MMD), usually 1.0-4.0 m MMD, and preferably 1.0-3.0 m MMD; a delivered dose of about 30%, usually 40%, preferably 50%, and most preferred 60%; and an aerosol particle size distribution of about 1.0-5.0 m mass median aerodynamic diameter (MMAD), usually 1.5-4.5 m MMAD, and preferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity.
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