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Detection of a leptin receptor variant and methods for regulating obesity
Detection of a leptin receptor variant and methods for regulating obesity
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机译:瘦素受体变体的检测和调节肥胖症的方法
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摘要
The present invention relates to a variant form of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down-regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system.
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