Method for enhancing outflow of aqueous humor in treatment of glaucoma

摘要

Elevated intra-ocular pressure is reduced by administration directly to the eye of compounds that inhibit function of a Na^+—K^+—2Cl^−2 cotransporter mechanism discovered in trabecular meshwork cells of mammalian eyes. These compounds are useful in treatment of diseases of the eye associated with elevated intra-ocular pressure, such as ocular hypertension and glaucoma. A screening method is provided to discover additional compounds with utility for lowering intra-ocular pressure by substantially inhibiting the Na^+—K^+—Cl^−2 cotransporter mechanism in trabecular meshwork cells.