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Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds
Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds
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机译:使用甲状腺激素化合物或类甲状腺激素化合物治疗皮肤皮肤萎缩
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摘要
The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, and comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base suitable for topical application, wherein the thyroid hormone compound or the thyroid hormone-like compound binds to TR- or TR- with an equilibrium dissociation constant, Kd, of at least 105 M. The invention is also directed to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating dermal atrophy of the skin.
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机译:本发明涉及治疗皮肤的皮肤萎缩的方法。本发明的方法包括将组合物施用于患有皮肤的皮肤萎缩的哺乳动物的皮肤上,并且包含至少一种甲状腺激素化合物或甲状腺激素样化合物以及适合局部施用的药理学可接受的基质,其中甲状腺激素化合物或类甲状腺激素化合物以至少10 5 Sup> M的平衡解离常数K d Sub>与TR-或TR-结合。本发明还涉及一种包含包装材料和包含在包装材料中的药剂的制品,其中所述药剂对于治疗皮肤的皮肤萎缩具有治疗有效作用。
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