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Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell
Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell
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机译:非哺乳动物DNA病毒在哺乳动物细胞中表达外源基因的用途
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摘要
Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by providing to a cell a therapeutically effective amount of a virus whose genome carries an exogenous, therapeutic gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.
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