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Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof
Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof
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机译:基因工程链霉菌链霉菌的混合蒽环类抗生素,其生产方法和用途
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摘要
The present invention relates to novel hybrid anthracyclines generated by cloning of fused genes in a mutated Streptomyces galilaeus strain DSM 11638. Said strain was obtained by mutagenization of the S. galilaeus wild type (ATCC 31615). The aglycone moieties of the compounds obtained are modified alkavinones, caused by the gene products introduces into the mutant, and the sugar moieties are those derived from the host strain, i.e. rhodosamine-2-deoxyfucose-2-deoxyfucose or 2-deoxyfucose-2-deoxyfucose-2-deoxyfucose, or the disaccharide or monosaccharide forms of these.
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