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Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
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机译:由新型二酰胺基二醇合成四酰胺基大环配体
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摘要
A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene) to yield the tetraamido macrocycle.
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机译:二酰胺基二醇的新物质组成和制备二酰胺基二醇的方法。示例性二酰胺基二醇具有式C 15 Sub> H 30 Sub> N 2 Sub> O 4 Sub>,并且通过使第一量反应而制备的2-氨基-2-甲基-1-丙醇与第二量的二取代的丙二酰二氯(即二乙基丙二酰二氯),优选在乙酸乙酯中作为溶剂。由二酰氨基二醇分两步制备四酰氨基大环,方法是将二酰氨基二醇氧化成二酸,然后使用二酸的已知方法与芳基二胺(例如1,2-二氨基苯)偶合,得到四酰氨基大环。
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