Imidazole Derivatives, cyclic analogs of somatostatin, Pharmaceutical composition containing same and Use thereof for the manufacture of a

摘要

1. Cyclic pyridinol analogues extracted from pyridinol, including formula compounds (1) or acceptable salts of drugs in the formula, in which y and Z are natural or unnatural d-o l-alpha-amino acids in each case, n is 0-50 in each case, but n is always 0 at the same time; M is an integer of 0 or 1 to 10; a is h or R1; B is oh-or1 o-nr9r9; or a combines with B to form an AM link; r1e is an independent h, asphalt (C1-4) or arilalquilo (C1-4);R2 is h, or an alternative part selected from enal quilo (C1-4) group,Phenyl, phenylpropyl (C1-4) and isopropyl hydrocarbyl (C1-4),Among the alternatives, the alternative share is replaced by one ohm alternative, and each ohm alternative is selected independently from the asphalt group (C1-4),Bicycle (C3-8),-O-R6 S (O) q-R7 -N (R9R9)-Nhco-r6, nso2r9, co2-r9, conr9r9 and so2nr9r9, wherein QES 0, 1, 2 or 3; each of R3 and R4 is an independent h, halogen or alternative substitute selected from the asphalt group (C1-4),Bicycle (C3-8),1. Arilo and arilalquilo (C1-4);One or more substitutes were selected from the oh tar (C1-4) group,alcoxi (C1-4)Ariloxi, arilalcoxi (C1-4) - nr9r9, cooh-conr9r9, and halo; or R3 and R4, together with the carbide connected with them, form an optional arilo. In ariloxi, one or more alternatives can be selected to replace arilo. Each alternative is selected independently from the oh asphalt (C1-4) group,alcoxi (C1-4)ariloxi arilalcoxi (C1-4)-Nr9r9 -, cour5 -, conr9r9, and halo; R5 is an alternative selected from the asphalt (C1-4) and arilalquilo (C1-4) groups, in each case, independent of H,When the selected industrial products are replaced by one or more substitutes, each substitute is selected independently from the asphalt group.