Process for preparing a formilfosfonico acid derivative, Process for preparing an Acid formilfosfonico,A Salt or hydrate thereof and process to prepare N - (PHOSPHONOMETHYL) glycine, or a Salt or Ester of the same

摘要

It reveals a process for the preparation of acid formilfosfonico,And its derivatives where the process involves DECOMPOSING a compound oxide (PHOSPHONOMETHYL) Amine in the presence of a catalyst to produce the derivative decomposition deu00e1ci OJ formilfosfoniCo and an Amine desfosfonometilada.Serevela also a process for the preparation of acid formilfosfonico, wherein the process comprises oxidize nitrilotris or a Salt thereof to will become - nitrilotris oxide or Salt Law,N - oxide and decompose the nitrilotris or Salt thereof in the presence of a catalyst decomposition.Anotherimportant of This relates to a process for preparing N - (PHOSPHONOMETHYL) glycine, or a Salt or Ester thereof,Where comprendedescomponer Windows approach or an oxide Compound (PHOSPHONOMETHYL) Amine in the presence of a catalyst to produce a Derivative of acid decomposition formilfosfonicoy des amineFosfonometilada, and react to produce deu00e1cido formilfo sfonico derivative N - (PHOSPHONOMETHYL) glycine, or a Salt or an ester of the same.Of particular interest is a realization of this process in which the Reaction for producing N - (PHOSPHONOMETHYL glycine) is achieved by condensaciondelderivado acid F with a ormilfosfonico conTo reduce the product of Glycine, and condensed to produce N - (PHOSPHONOMETHYL glycine).Another aspect which is of particular interest is one in which the Derivative of formilfosfonico secondensa acid with 1 - amino - 2 - roxietano HID to produce a intermediarioalcoholico condensateThe intermediary alcoholic condensate is reduced to produce a compound N - (2 - hydroxyethyl) - N - (PHOSPHONOMETHYL) amineAnd the compuestoden - (2 - hydroxyethyl) - N - (PHOSPHONOMETHYL) Amine is oxidiza pa ra producing N - (PHOSPHONOMETHYL glycine).The formilfosfonico acid can be used as a precursor in the synthesis of N - (PHOSPHONOMETHYL glycine), a highly effective Commercial herbicide.The u00e1cidoformilfosfonico can alternatively be used as a ermediarioavanzado int in the preparation of compounds of medicinal importance such as an antiviral agent fosfonohidroxiac acidEthical.