Crystal form and solid form of celecoxib, pharmaceutical composition and processes for treating or preventing a cyclooxygenase-2 mediated condition or disorder in an individual and for preparing celecoxib and a crystalline form of celecoxib

摘要

"CRYSTALLINE FORM AND SOLID FORM OF CELECOXIB, PHARMACEUTICAL COMPOSITION AND PROCESSES TO TREAT OR PREVENT A CONDITION OR DISORDER MEDIATED BY CYCLEOXYGENASE-2 IN AN INDIVIDUAL AND TO PREPARE CELECOXIBAL AND A FORM. Pharmaceutical compositions are provided that comprise one or more dosage units that can be administered orally, each comprising a selective cyclooxygenase-2 inhibitor compound of low water solubility in a therapeutically effective amount, wherein the compound is present in the form of particles solids, approximately 25% to 100% by weight of which are less than 1 mm. The compositions are useful in the treatment or prophylaxis of conditions and disorders mediated by cyclooxygenase-2 and have special advantages when a rapid onset of therapeutic effect is desired. The new crystalline forms Form I and Form II are described. Crystalline forms have exceptional chemical and physical properties compared to other solid state forms of celecoxib and are characterized by their powder X-ray diffraction pattern (PXRD), their differential scanning calorimetric thermograms (DSC) and other characterizations physical.