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Use of biodegradable microspheres that release a radiosensitizing anti-cancer agent, process of preparing biodegradable microspheres, and suspension consisting of a sterile solution
Use of biodegradable microspheres that release a radiosensitizing anti-cancer agent, process of preparing biodegradable microspheres, and suspension consisting of a sterile solution
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机译:使用可释放放射增敏抗癌剂的可生物降解微球,制备可生物降解微球的方法以及由无菌溶液组成的悬浮液
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摘要
"USE OF BIODEGRADABLE MICROSPHERES THAT RELEASE A RADIOSENSITIZING ANTICANCERATE AGENT, PROCESS OF PREPARING BIODEGRADABLE MICROSPHERES, AND A CONSTITUTED SUSPENSION OF A STERILE SOLUTION". The object of the present invention is the use of biodegradable microspheres that release an anti-cancer radiosensitizing agent for the manufacture of a medicine intended to be used simultaneously, separately or distributed over time, with radiotherapy, for the treatment of glioblastoma. The use of the biodegradable microspheres according to the invention allows to achieve a survival time of the patients of at least 90 weeks, maintaining, over time, a therapeutically effective concentration in the parenchymal space. The microspheres used preferably contain 5-fluoroacil coated with poly (d, 1-lactic acid-co-glycolic acid). The microspheres are implanted by intratissular injection, after excision of the tumor, in the walls of the surgical focus. Radiotherapy focused on tumor volume is dosed at 60 Gy over approximately six weeks. The present invention also relates to a process for preparing the biodegradable microspheres by emulsion-extraction, as well as a suspension containing biodegradable microspheres eventually obtained by means of this process.
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