Invention Patent "MACROLYDE ANTI-INFECTIOUS AGENTS". Compounds of formula (1), (2) or (3), in which R ~ a ~ is H; (1 - 10C) substituted or unsubstituted alkyl; (2 - 10C) substituted or unsubstituted alkenyl; (2 - 10C) substituted or unsubstituted alkynyl; (4 - 14C) substituted or unsubstituted aryl; (5 - 20C) substituted or unsubstituted arylalkyl; or OR ~ a ~ is replaced by H; R ~ b ~ is H or halogen; R ~ and ~ is H or a protecting group; R ~ d ~ is methyl, (3 - 10C) unsubstituted alkyl; (1 - 10C) substituted alkyl; (2 - 10C) substituted or unsubstituted alkynyl; (4 - 14C) substituted or unsubstituted aryl; (5 - 20C) substituted or unsubstituted arylalkyl; (5 - 20C) substituted or unsubstituted arylalkenyl; (5 - 20C) substituted or unsubstituted arylalkynyl; (5 - 20C) substituted or unsubstituted amidoarylalkyl; (5 - 20C) substituted or unsubstituted amidoarylalkenyl; or (5 - 20C) substituted or unsubstituted amidoarylalkynyl; R ~ and ~ is H or a protecting group; L is methylene or carbonyl; T is -O-, -N (R) -, -N (OR) -, -N (NHCOR) -, -N (N = CHR) -, or -N (NHR) - where R is H or R ~ a ~ as defined above, with the proviso that when L is methylene, T is -O-; one among Z and Y is H and the other is OH, OH protected, or amino, mono- or dialkylamino, protected amino, or an amino heterocycle or Z and Y together are = O, = NOH or a derivatized oxime; including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof, are antimicrobial agents.
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