Isolated nucleic acid molecule, fusion polypeptide, composition, vector, vector system, host vector system, methods of producing a fusion polypeptide.

摘要

"ISOLATED NUCLEIC ACID MOLECULE, FUSION POLYPEPTIDE, COMPOSITION, VECTOR, VECTOR SYSTEM, HOST, METHOD OF PRODUCING A FUSION POLYPEPTIDE, AND USE OF A FUSION POLYPEPTIDE". Chimeric polypeptides modified with improved pharmacokinetics are disclosed. Specifically, modified chimeric Fltl receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and / or vascular permeability in a mammal.