Indazole compounds, pharmaceutically acceptable prodrug, pharmaceutically active metabolite, or pharmaceutically acceptable salt, pharmaceutical compositions, method for treating a mammalian disease condition mediated by protein kinase activity and method for modulating the activity of a protein receptor protein kinase

摘要

"INDAZOL COMPOUNDS, PHARMACEUTICALLY ACCEPTABLE PRO-DRUG, PHARMACEUTICALLY ACTIVE METABOLITE, OR PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITIONS, METHOD OF TREATING AN ACTIVE HARMFUL MEDICINE HARMFUL TREATMENT PROTEIN KINASE ". Indazole compounds have been described that modulate and / or inhibit the activity of certain protein kinases. These compounds and the pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction, and thereby modulate and / or inhibit unwanted cell proliferation. The invention also relates to the therapeutic or prophylactic use of pharmaceutical compositions containing these compounds and to methods of treating cancer and other disease states associated with unwanted angiogenesis and / or cell proliferation, such as diabetic retinopathy, neurovascular glaucoma , rheumatoid arthritis, and psoriasis, by administering effective amounts of these compounds.