Use of a replication-deficient adenoviral vector, and methods to enhance, and to induce, cd8 + t cell immune response to an antigen in an individual

摘要

"USE OF A DEFICIENT ADENOVIRAL VECTOR IN REPLICATION, AND, METHODS FOR STRENGTHENING, AND TO INDUCT IMMUNE RESPONSE OF CD8 + T CELL TO AN ANTIGEN IN AN INDIVIDUAL". Use of a replication-deficient adenoviral vector encoding a CD8 + T cell antigen or antigen to enhance the individual's CD8 + T cell immune response to the antigen after previous administration of an initiation composition. The initiation composition comprises the antigen or epitope or nucleic acid encoding the antigen or epitope and can be DNA, Ty-LVP's or modified ankara virus (MVA). Administration can be intradermal or intramuscular.