Process for the formation of a group of mono primary phosphorylates a functionality of 1,2 - diol - propanu00f3ila terminal, processes for the preparation of 5 - (HET - X - methyl) - 3 - (4 - (1 - benzyl - 1,2,5,6 - tetraidropirid - 4 - YL) - 3.5 - difluorofenil) oxazolidin - 2 - ona, and 5 - isoxazol - 3 - iloximetil - 3 - (4 - (1 - benzyl - 1,2,5,6 - tetraidrop Irid - 4 - YL) - 3.5 - difluorofenil) oxazolidin - 2 - ona, and.Intermediate compound quu00ecmico

摘要

Process for the formation of a group of monofosforila primary functionality of 1,2 - diolpropanou00ecla terminal, processes for the preparation of 5 - (HET - X - methyl) - 3 - (4 - (1 - benzyl - 1,2,5,6 - tetraidropirid - 4il) - 3, 5 - difluorofenil) oxazolidin - 2 - ona, and 5 - isoxazol3 - iloximetil - 3 - (4 - (1 - benzyl - 1,2,5,6 - tetraidropi rid - 4 - YL) - 3,5difluorofenil) oxazolidin - 2 - ona, and.Intermediate compound quu00ecmico ".The invention relates to chemical processes and chemical intermediates which are useful in the formation of a selective group of mono phosphorylates primary (- OPO (oh ~ 2 ~)) in a system containing 1.2 - diol - propanou00edla (Hoch ~ 2 ~ ch (OH) - co) terminal.The chemical processes and chemical intermediates and processes for their manufacture) are particularly useful for the manufacture of oxazolidinone agents anti gram positive bacterial containing such Fu.Ncionalidade, particularly for the preparation of 5 (R) isoxazol - 3 - iloximetil - 3 - (4 - (1 - (2 (s) - hydroxy - 3 - fosforil - propanoil) - 1,2,5, 6 - tetraidropiridi - 4-yl) 3,5 - difluorofenil) oxazolidin - 2 - one.