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Method of protection to identify indu00ecviduos with risk of developing diseases associated with different polymorphic forms of wild type p53

机译:鉴定具有发展为与野生型p53不同多态性形式相关疾病的风险的个体的保护方法

摘要

Invention patent "method of protection for determination of indivu00ecduos with risk of developing diseases associated with different polymorphic forms of p53 of wild type".The present invention relates to the method of protection to identify individuals at risk of developing diseases associated with different polymorphic forms of p53 that compreend natural;And the steps of: a) obtaining a biological sample from said patient; and (b) determining the presence of alleles p53pro or p53Arg of wild type in the sample, where the pattern of the patient selecio alleleSwim from the group consisting of p53pro / p53pro,P53Arg / p53Arg and p53pro / p53Arg is indicative of a risk factor for the development of diseases associated with the various polymorphic forms of the type p53 natural.Remarkably, individuals who are p53Arg / Arg have a major risk factor for the development of pathologies associated with infections of human papillomavirus and cervical cancer.
机译:发明专利“用于确定具有发展与野生型p53的不同多态性形式相关的疾病的风险的个体的保护方法”。本发明涉及一种鉴定具有发展与之相关的疾病的风险的个体的保护方法包含天然的p53的不同多态形式;以及以下步骤:a)从所述患者那里获得生物学样品; (b)确定样品中是否存在野生型等位基因p53pro或p53Arg,其中来自p53pro / p53pro,P53Arg / p53Arg和p53pro // p53Arg的患者selecio等位基因Swim的模式指示与p53型自然多态性相关的疾病发展的危险因素。值得注意的是,p53Arg / Arg个体是与人乳头瘤病毒和宫颈癌感染相关的病理发展的主要危险因素。

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