Composition comprising extract of hoptimizadas tumor cells to tumor cells, where the cells are unable to conjugate hopteno Multiply and grow in vivoUseful for Inducing an antitumor response.

摘要

This Invention relates to compositions comprising haptenizadas tumor cells and extracts thereof, Methods for preparing the compositionsVaccines comprising such haptenizadas tumor cells, and Methods for the treatment of cancer with such Vaccines.In a specific realization, melanoma cells are haptenizadas with a group dinitrofenilo,And used for the treatment of patients with melanoma who have disease matastasica.Preferably provides patients with the first doses of vaccine containing cells haptenisadas as priming of the immune system.Subsequently, patients are injected with an immunomodulatory Compound such as Cyclophosphamide.In a Preferred embodiment in a period of time after the dose of vaccine apropopiado primer is administered additional doses of vaccine containing a mixture of cells hasPtenizadas and an adjuvant. The Plan of treatment described is more effective to stimulate favorable anti tumor immune responses.