Antibody Molecule that has specificity for tumor necrosis factor alpha (TNF alpha) Human CDR grafted Antibody peguilados, Antibodies, DNA, vectors, host cells,Procedure of production, compositions useful for the treatment of rheumatoid arthritis or Osteoarthritis.

摘要

Antibodies are molecules that contain at least one CDR derived from a Mouse monoclonal antibody that has specificity for the Human TNFa.It also reveals a CDR grafted Antibody where at least one of the CDR CdR is a Hybrid.In addition to reveal DNA sequences that Encode the chains of the Antibody Molecules, vectors,Transformed host cells and Uses of the molecules (Antibodies in the treatment of diseases mediated by TNFa.