Ethers compounds derived from (S) - 2 - hydroxy - 3 - (piperidin-4-yl ilmetilamino and ethylamine) - propyl substituted 2 - aryl - 2 - (R) - hydroxy - (1 - methyl - 4 - substituted 2-piperidyl),Pharmaceutical composition useful for treating Metabolic Disorders mediated by insulin resistance or hyperglycemia, urinary incontinence and inflammations.

摘要

The present Invention relates to compounds of the formula I with the structure where a, B, Z,R1 and R are as defined above or a pharmaceutically acceptable Salt thereof,Which are appropriate in the Treatment or inhibition of Metabolic Disorders related to Resistance to insul9ina or hyperglycemia (typically associated with Obesity or intoleranceThe arteriosclerosis Glucose), gastrointestinal disorders, neurogenetic inflammation, glaucoma,Ocular hypertension and frequent urination and are particularly appropriate in the Treatment or inhibition of diabletes of Type II.