Derivatives of pyrrolidine compounds 1,4 - heterosustituidos, Preparation procedure,Pharmaceutical Composition and its use in the prophylaxis and Treatment of disorders caused by the activity of the Endothelin converting Enzyme (ECE) and Myocardial Ischemia.Hypertension and Asthma.

摘要

The present Invention relates to compounds of the formula I wherein R1, R2, R3, R4.R5 and x are as defined in the description and Claims, and esters and / or the pharmaceutically acceptable salts of the same.The compounds are useful as inhibitors of metalloproteases, e.g.Zinc proteases, in particular zinc Hydrolases, and which are effective in the treatment of Disease States associated with the increasing incidents of vaso constriction.