Formulations of Quetiapine in granule, its preparation and its use

摘要

A granule formulation comprising 11 (4 - (2 - (2-hydroxyethoxy) ethyl) - 1-piperazinyl) dibenz (B, F (1),4) thiazepine or a pharmaceutically acceptable Salt thereof and a Binder free or very Soluble in water, where the gru00e1nulostienen a Density range of 0.15 g / cm3 volume of 0.60 g / cm3 and a range of density of 0.20 g / cm3 to 0.70 g / cm3 and 80% of the Granules are in the size range of 75 Micron up to 850 microns.A process for preparing a formulation as defined in claim 1 which comprises: (i) fluidise one or more components on a Bed of Air in a Fluid bed; (ii) addThe Fluid bed, Water optionally containing one or more components; (iii) drying.