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Bioadhesive hydrogels with functionalized degradable transverse bonds
Bioadhesive hydrogels with functionalized degradable transverse bonds
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机译:具有功能性可降解横向键的生物粘附水凝胶
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摘要
This invention relates to A bioadhesive composition comprising two or more essentially excretable, essentially non-degradable polymer backbones, wherein the polymer backbones are crosslinked, said crosslink being degradable in a mammal, said cross-linked bioadhesive composition having an average bioadhesion factor showing bioadhesion equivalent to at least about 100 g s. The concept is to build a hydrogel that demonstrates bioadhesion to a mucosal surface that is crosslinked by a degradable linkage such as disulfide for use inside the body.
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机译:本发明涉及一种生物粘合剂组合物,其包含两个或更多个基本上可排泄的,基本上不可降解的聚合物主链,其中所述聚合物主链是交联的,所述交联在哺乳动物中是可降解的,所述交联的生物粘合剂组合物具有平均生物粘附因子,显示出生物粘附等效性。至少约100 g s。构想是制造一种水凝胶,该凝胶表现出对粘膜表面的生物粘附性,该粘膜表面通过可降解的键(如二硫键)交联,可在体内使用。
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