METHOD FOR PREPARING 4-ACETOXY-2ALPHA-BENZOYLOXY-5BETA,20-EPOXY-1,7BETA,10BETA-TRIHYDROXY-9-OXO-TAX-11-EN-13ALPHA-YL(2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE TRIHYDRATE

摘要

The present invention relates to a process for the preparation of the known 4-acetoxy-2β- (benzoyloxy) -5β, 20-epoxy-1,7β, 10β-trihydroxy-9-oxotaxa-11-ene-13β- yl (2R, 3S) -3 - [(tert-butoxycarbonyl) amino] -2-hydroxy-3-phenylpropionate-trihidrátelőállítására. The trihydrate form is prepared by crystallizing the anhydrous form from a mixture of water and a C1-C3 alcohol, preferably in the presence of ascorbic acid, and then drying the resulting crystals at a specified temperature, pressure and humidity. ŕ