PROCESS FOR PRODUCING 1,2,4-BENZOTRIAZIN-OXIDE DERIVATIVES APPLICABLE AS RADIATION SENSITIZER AND SELECTIVE CYTOTOXIC AGENT, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention relates to novel compounds of formula (I) for the preparation of pharmaceutical compositions containing them, wherein: i) X is -NHR-, where R is (C1-C4 alkylamino) - (1-4C) alkyl or di; (C1-C4 alkylamino) - (1-4C) alkyl, and Y1 and Y2 are hydrogen or halogen or nitro or ii) X is -NH2 and Y1 and Y2 one of the hydrogen atoms, and the other nitro group, iii) X is hydrogen, C 2-4 alkyl, C 2-4 alkenyl, 2 to 4 carbon atoms substituted with one or more hydroxyl groups, 1 to 4 carbon atoms or halogen, and Y 1 to Y 2 one is hydrogen and amines are hydrogen or nitro, provided that when Xhydrogen is one of Y1 and Y2 is a nitro group. ŕ