USE OF aIL- AGONISTS FOR PREPARING PHARMACEUTICAL COMPOSITIONS FOR TREATING URINARY INCONTINENCE, SOME PHENYLIMINOIMIDAZOLIDINE DERIVATIVES AND A PROCESS FOR THEIR PREPARATION

摘要

Use of aIL-agonists for the preparation of pharmaceutical compositions for treating urinary incontinence, particularly stress incontinence substantially as described in the specification. Phenyliminoimidazolidines of the formula 2961 י' בכסלו התשס" ב - November 25, 2001 wherein R1 denotes hydrogen, C1-6-alkyl, C3-6-cycloalkyl, C1-6-alkoxy; halogen, -CF3 or OCF3; R2 denotes -NR6R7 wherein R6 is hydrogen, C1-6-cycloalkyl, C1-6-alkyl, C2-4-acyl, R7 is hydrogen, C3-6-cycloalkyl, C1-6-alkyl, C2-4-acyl, or R6 and R7 together with the nitrogen atom form a 5- or 6-membered saturated or unsaturated ring which may contain up to two further heteroatoms from the group comprising oxygen, sulphur or nitrogen, whilst each additional nitrogen atom may be substituted by C1-4-alkyl, preferably methyl; or R6 and R7 together with the nitrogen atom form phthalimido; R3 denotes hydrogen, halogen, C1-6-alkyl, C1-6-alkoxy, -CF3 or -OCF3; R4 denotes hydrogen, C1-6-alkyl or halogen; R5 denotes hydrogen, C1-6-alkyl, C1-6-alkoxy, halogen, -CF3 or -OCF3, and the pharmaceutically acceptable acid addition salts thereof, with the exception of 2-(3-Acetamido-2,6- dibromophenylimino)- imidazolidine, 2-(3-Acetamido-2,6-diethylphenylimino) -imidazolidine, 2-(3-Acetamido-2,6- dimethylphenylimino)-imidazolidine, 2-(3-Acetamido-2,6- dibromophenylimino)-imidazolidine, 2-(3-Amino-2,6- dichloro-4- methylphenylimino)- imidazolidine, 2-(3-Amino-2,6- dichloro-4- methylphenylimino)- imidazolidine- Dihydrochloride, 2-(3-Amino-2,6- dichlorophenylimino)- imidazolidine, 2-(3-Amino-2,6- dichlorophenylimino)- imidazolidine-Hydrochloride, 2-(3-Amino-2,6- diethylphenylimino)- imidazolidine, 2-(3-Amino-2,6- diethylphenylimino)- imidazolidine-Dihydrochloride, 2-(3-Amino-2,6- dimethylphenylimino)- imidazolidine, 2-(3-Amino-2,6- ditrifluoromethylphenylimino)- imidazolidine, 2-(3-Amino-4- fluorophenylimino)- imidazolidine, 2-(3-Amino-6-chloro-4- methylphenylimino)- imidazolidine, 2-(3-Amino-6-chloro- 4-methylphenylimino)- imidazolidine- Dihydrochloride, 2-(3-Diethylamino-2- methylphenylimino)- imidazolidine, 2-(5-Amino-2,4- dibromo-6- fluorophenylimino)- imidazolidine, 2-(5-Amino-2,4- dibromophenylimino)- imidazolidine, 2-(5-Amino-2,4- dichloro-6- fluorophenylimino)- imidazolidine, 2-(5-Amino-2,4- dichlorophenylimino)- imidazolidine, 2-(5-Amino-2,4- dimethylphenylimino) -imidazolidine, 2-(5-Amino-2-bromo- 4-chloro-6- fluorophenylimino)- imidazolidine, 2-(5-Amino-2-bromo-4-fluorophenylimino)- imidazolidine, 2-(5-Amino-2-bromophenylimino)- imidazolidine, 2-(5-Amino-2- chloro- 4-fluorophenylimino)- imidazolidine, 2-(5-Amino-2- chlorophenylimino)- imidazolidine, 2-(5-Amino-2-chlorophenylimino)- imidazolidine-Hydrochloride, 2-(5-Amino-2- methylphenylimino)- imidazolidine, 2-(5-Amino-2- methylphenylimino)- imidazolidine- Dihydrochloride, 2-(5-Amino-4-bromo-2- chloro- 6-fluorophenylimino)- imidazolidine are claimed as novel.