SUBSTITUTED IMIDAZO1,2A AZINES ASSELECTIVE INHIBITORS OF COX-2

摘要

The present invention relates to new products of formula (I) wherein A and B are selected amongst N and CH, with the condition that when A is N, B is N; R1 is selected amongst CH¿3? and NH2; R?2 and R3¿ are selected amongst H, CH¿3?, Br, Cl, COCH3 and OCH3; R?4, R5 and R6¿, which are similar or different, are selected in the group comprised of H, F, Cl, Br, (C1-C3)-alkyl, trifluoromethyl, (C1-C3)-alkoxyl and trifluoromethoxyl. The products of formula (I) are prepared by condensation between a substituted aminoazine and a substituted 2-bromo-2-(4-R1-sulfonylphenyl)-1-phenyltanone in a polar solvant. These new compounds have an activity which inhibits COX-2, with high selectivity in relation to COX-1. They are useful for the treatment of inflammation and/or diseases mediated by cyclo-oxigenases, with the additional advantage that they have a reduced ulcerogenic potential.