REPLICATION-DEFECTIVE RECOMBINANT ADENOVIRUS WITH MUTATED MAJOR LATE PROMOTER.

摘要

The present invention provides a recombinant adenovirus having a genome with a deficiency in the E1 region and a mutation in the MLP. The invention also provides stocks of such viruses and compositions including the inventive viruses. The invention also provides cell lines for propagating the recombinant adenoviruses.