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Use of cyclohexane polycarboxylic acids as plasticizers in prodn. of plastics which are rated toxicologically favourable
Use of cyclohexane polycarboxylic acids as plasticizers in prodn. of plastics which are rated toxicologically favourable
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机译:产品中环己烷多元羧酸作为增塑剂的用途。被评为在毒理学上有利的塑料
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摘要
The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.
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