MESYLATE TRIHYDRATE SALT OF 5-(2-(4-(1,2-BENZISOTHIAZOL-3-YL)-1- -PIPERAZINYL)ETHYL)-6-CHLORO-1,3-DIHYDRO-2(1H)-INDOL-2-ONE (=ZIPRASIDONE), PHARMACEUTICAL COMPOSITION BASED THEREUPON AND METHOD OF TREATMENT OF PSYCHOTIC DISORDERS

摘要

PCT No. PCT/IB97/00306 Sec. 371 Date Mar. 2, 1999 Sec. 102(e) Date Mar. 2, 1999 PCT Filed Mar. 26, 1997 PCT Pub. No. WO97/42190 PCT Pub. Date Nov. 13, 1997Mesylate Trihydrate Salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one (=Ziprasidone), Its Preparation and Its Use as Dopamine D2 Antagonist The invention relates to the mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one ("ziprasidone mesylate trihydrate"), to pharmaceutical compositions containing ziprasidone mesylate trihydrate, and to methods of administering ziprasidone mesylate trihydrate to treat psychotic diseases.