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FROZEN SUSPENSION OF GAS MICROBUBBLES IN FROZEN AQUEOUS CARRIER FOR USE AS CONTRAST AGENT IN ULTRASONIC IMAGING
FROZEN SUSPENSION OF GAS MICROBUBBLES IN FROZEN AQUEOUS CARRIER FOR USE AS CONTRAST AGENT IN ULTRASONIC IMAGING
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机译:冷冻中的气体微泡在超声成像中作为造影剂使用
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摘要
Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 mu m, preferably below 10 mu m and more preferably between 2 mu m and 8 mu m, to a temperature between -1 DEG C. and -76 DEG C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.
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