Truncated VEGF-B, VEGF-C, VEGF-3, PlGF, VRF-2, poxvirus ORF-1 and ORF-2 proteins

摘要

Provided are truncated forms of vascular endothelial growth factor-related proteins (VRPs) which are useful for stimulation of angiogenesis in vitro and in vivo. The truncated VRP subunits selected from VEGF-B, VRF-2, VEGF-C, PlGF, poxvirus ORF-1 and poxvirus ORF-2 have a deletion of at least one of the amino acid residues N-terminal to the first cysteine of the core sequence of the subunit. Gene therapy using the nucleic acids which code for the truncated VRPs may be useful for the treatment of heart disease and for wound healing.