A 3-[1,2,3-triazolo[4,5-d]pyrimidin-3yl]-cyclopentane derivative or a pharmaceutically acceptable salt or solvate thereof has the formula (I) wherein: R1 is an optionally substituted alkyl, alkenyl, cycloalkyl or a phenyl group; R2 is an optionally substituted alkyl or cycloalkyl group; one of R3 and R4 is hydroxy and the other is hydrogen, hydroxy or NR9R10; R is (CR4R6)mOR7; an optionally substituted alkyl or alkenyl group each of which is already substituted by =S, =O, =NR20 or OR21; m is 0 or 1; R5 and R6 are independently hydrogen or optionally substituted alkyl or phenyl; R7 is hydrogen, alkyl or (CR5R6)nR14; n is 1 to 3; R14 is COOH, OR15, NR16R17 or CONR16R17; R9 and R10 are independently hydrogen or alkyl; R15, R16 and R17 are independently hydrogen or alkyl; R20 is OR24 or NR25R26; R21 is H, alkyl or phenyl and R24 to R26 are as defined in the specification. A pharmaceutical composition thereof useful is for treatment or prevention of myocardial infarction, thrombotic stroke, transient ischaemic attacks, peripheral vascular disease and angina.
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