Composition which have inhibitory effects of polyanionic substances on replication of herpes simplex virus (HSV) and other viruses such as human immunodeficiency virus (HIV)

摘要

A composition provided by extraction and purification from the spikes of Prunella vulgaris. The compositions are effective agents for treatment of the cytopathogenic effects of an enveloped virus in mammals. In the preferred embodiment, there are provided methods for the treatment of the cytopathogenic effects of an enveloped virus and related indications in mammals, employing the compositions as the active agent. Further described are that the compositions are effective agents for the treatment of the cytopathogenic effects of an enveloped virus in mammals exposed to immunosuppressive regimens. The compositions also provide an effective agent for protecting mammals from reactivated viral infection during or following treatment with chemotherapeutic agents. Also provided are methods for preparing extracts of Prunella vulgaris having antiviral action and the formulations containing such extracts. The method for purification and characterisation of the active fraction from Prunella vulgaris useful for treating the cytopathogenic effects of an enveloped virus in a mammal is described. The compositions are effective agents for the prophylaxis and therapy in mammals of diseases caused by enveloped viruses.