首页> 外国专利> Polyethylene glycol-polyorthoester, polyethylene glycol-polyorthoester-polyethylene glycol, and polyorthoester-polyethylene glycol-polyorthoester block copolymers

Polyethylene glycol-polyorthoester, polyethylene glycol-polyorthoester-polyethylene glycol, and polyorthoester-polyethylene glycol-polyorthoester block copolymers

机译:聚乙二醇-聚原酸酯,聚乙二醇-聚原酸酯-聚乙二醇和聚原酸酯-聚乙二醇-聚原酸酯嵌段共聚物

摘要

A block copolymer of formula (I), formula (II) or formula (III) in which m and n are independently an integer from 5 to 500; p and q are independently an integer from 5 to 500; R1 and R2 are independently C1-C4 alkyl; R3 is H or C1-C4 alkyl; and A is -O-R4-, -O-R5-, or a mixture thereof; R4 is selected from the structures depicted by (IV), where t is an integer from 1 to 12, R6 is C1-C4 alkyl, and R7 is H or C1-C4 alkyl; R5 is depicted by (V) in which x is an integer from 1 to 10, and R8 is H or C1-C6 alkyl. Also described is a micellar pharmaceutical composition for the delivery of a hydrophobic active agent, comprising the active agent physically entrapped within but not bonded to a drug carrier.
机译:式(I),式(II)或式(III)的嵌段共聚物,其中m和n独立地为5至500的整数; p和q独立地是5至500的整数; R1和R2独立地为C1-C4烷基; R3是H或C1-C4烷基; A为-O-R4-,-O-R5-或其混合物; R4选自(IV)所示的结构,其中t是1至12的整数,R6是C1-C4烷基,并且R7是H或C1-C4烷基; R5用(V)表示,其中x是1-10的整数,R8是H或C1-C6烷基。还描述了用于递送疏水性活性剂的胶束药物组合物,其包含物理上截留在药物载体中但不与药物载体结合的活性剂。

著录项

  • 公开/公告号NZ508301A

    专利类型

  • 公开/公告日2002-09-27

    原文格式PDF

  • 申请/专利权人 ADVANCED POLYMER SYSTEMS INC;

    申请/专利号NZ19990508301

  • 发明设计人 HELLER JORGE;NG STEVEN Y;

    申请日1999-05-28

  • 分类号C08G63/664;C08L71/02;A61K9/51;A61K9/20;

  • 国家 NZ

  • 入库时间 2022-08-22 00:44:02

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