Pharmaceutical compositions of estrogen agonists / antagonists and statins to treat osteoporosis and reduce cholesterol

摘要

Refers to a composition comprising: a) an estrogen agonist or antagonist of formula I where is CH, nr; b, D and e are CH, N; and phenyl, naphthyl, cycloalkyl - C8 cicloalquenilo C3, C3, C8,Five Member heterocycle, bicyclic Ring; Z1 is (CH2) PW (CH2) Q, o (CH2) pcr5r6 or (CH2) PW (CH2) Q, among others; g is nr7r8, Amine Group, biciclica; Z2 is NH, o, S, W is CH2 = CH2, CH; CH or NR2, S (n, o)Among others, R IS h, alkyl of C1 - C6; R2 and R3 are h, c1-c4 alkyl; R4 is H, halogen, alkyl of C1 - C6, among others; R5 and R6 are alkyl C1 - C3 - are carbociclo C8, C10; R7 and R8 are phenylCarbociclo C10 heterocycle Ring C3, C3 - C10, h; e and N are 0 - 2; M is 1 - 3, P and q are 0 - 3; being a Preferred Compound cis - (-) - phenyl - 5 6 - [4 - (2 - 1) - pyrrolidin-3-yl - iletoxi) phenyl] - 5,6,7,8 - tetrahidronaftalen - 2-ol, tamoxifen, Raloxifene, among others; (b) such as a statin simvastatin, mevastatin pravastatin, atorvastatin, cerivastatin, lovastatin, among others.The composition can be useful for Stimulating bone formation; prevent bone loss or reduce cholesterol, Treat hyperlipidemia