Pharmaceutical composition comprising an inhibitor of aldosterone synthase and an antagonist of angiotensin II receptor (AT1)

摘要

Refers to the use of a Pharmaceutical composition comprising: (a) as aldosterone synthase inhibitor fadrozole anastrozole, or its enantiomer of formula II,Exemestane; (b) an angiotensin II AT1 receptor antagonist alone or combined with a diuretic such as hydrochlorothiazide; AT1 Receptor Antagonist Losartan, valsartan is selected.Eprosartan, candesartan, irbesartan, The Compound of formula I, among others, and (c) a pharmaceutically acceptable vehicle.The composition is useful for the Prevention or treatment of hypertension, congestive heart failure, atherosclerosis, insulin resistance and endothelial dysfunction