Piperidine derivatives as Selective antagonists of receptor subtypes n-methyl-d-aspartate

摘要

Refers to piperidine Derivatives of formula I wherein R1 is alkyl, alkoxy, alquilaminoalquilo alquenilo, among others; g is 0 - 3; H is 0 - 1; R2 and R3 are h, Oh, alkoxy, V is N (CH2)MK = o (CH2); n is 1 - 4; M is 0 - 4; b is 1 - aza - 2 - ciclobutanon - 3.4 - dilaurate, dirradical Aromatic heterocycle,No Aromatic or non Aromatic Tetrahydro Dihydro 5 members; dirradical Aromatic heterocycle substituted tetrahydro - oxo 5 members,Dirradical Aromatic heterocycle Aromatic or non Aromatic Tetrahydro not hexahidro 6 membersHeterocycle substituted Aromatic oxo not dirradical hexahidro with 6 members; heterocicleno Atoms which are attached to V and the phenyl Group is (x1) D are carbon Atoms; when BIs a Aromatic heterocycle containing can not understand and S = s or - S - (= o) 2; x1 is alquenilo, alkyl, alkoxy, aralquilo, halogen, Nitro, amino, haloalquilo,Among others; d is 0 - 2; e h o e,; and;And along with the phenylene Ring bicyclic form a condensate of 9 - 10 members; and 2 Atoms of the bicyclic Ring; and is a donor of hydrogen Atom contains a bicyclic ring.Preferred compounds are 6 - [5 - (4 - bencilpiperidin - 1 - methyl isoxazole) - 4,5-dihydro - - 3 - yl] - 3H - benzoxazole - 2 - One; (+) - 6 - (5 - [4 - (4-fluorobenzyl) piperidin-1-ylmethyl) - 4Dihidroisoxazol - 3 - 5 - il} - 3H - benzoxazole - 3-one among others.The compounds are antagonists of n-methyl-d-aspartate (NMDA) and may be useful for the treatment of Stroke, cerebral ischemia, CNS Disorders