Imidazole derivatives as blockers of receptor, n-methyl-d-aspartate

摘要

Refers to imidazole Derivatives of formula I where is phenyl, pyridin-2-yl, pyridin-3-yl) piperidin-1-yl; R1 and R2 are h, halogen, alkyl, cycloalkyl, alquenilo, trifluoromethyl,- or trifluoromethyl, among others; R3 is H, alkyl, cycloalkyl, phenyl, alkyl, amino, among others; R4 and R5 are h, alkyl or next to C form (CH2) 4; R6 and r6 'is H, alkyl; X is n, c = and = N,NH, n = CH, CH = N; Z is nr7 CR7 =, =, =, N CR7, among others; CH2OH R7 is H, alkyl; n is 0 - 2; M is 0 to 1.Preferred compounds are 1h imidazole, 1 - [1 - (4 - chlorine - 3-methylphenyl) - 1H imidazole - 4-yl] methyl] - 2 - Ethyl; 1h imidazole, 1 [[1 - (4 - chlorine - 3-methylphenyl) - 1H imidazole - 4 - il] methyl] - 2 - methyl - 1 - (3,4 - Dichloro phenyl) - 3 - (2 - methyl - imidazol-1-yl - methyl) - 1H pyrazole, among others. It also relates to a process for Preparation.The compounds are specific blockers of receptor subtype n-methyl-d-aspartate (NMDA) and may be useful for the treatment of Neurodegenerative Diseases, Alzheimer's disease, Parkinson's disease,Huntington's disease, Amyotrophic lateral sclerosis, neurodegeneration associated with viral and bacterial infections, depression