Alternatives to 4-Phenyl-1 - (1-phenyl-cyclohexane) - 1,2,3,6-tetrahydro-pyridine, their preparation procedures, drugs containing these compounds

摘要

It refers to 4-Phenyl-1 - (1-phenyl-cyclohexane) - 1,2,3,6-tetrahydro-pyridine, which is replaced by a formula, wherein R1 is C1-C5 tar, halogen without 4-chlorine, or - C1-C5 tar, s-c1-c5. The most popular are 4 - (4-fluoro-phenyl) - 1 - (1-phenyl-cyclohexane) - 1,2,3,6-tetrahydropyridine, 4 - (3-fluorophenyl) - 1 - (1-phenyl-cyclohexane) - 1,2,3,6-tetrahydropyridine, etc. He also mentioned a preparatory process These compounds are closely related to the receptor of ORL-1 and can be used to treat pain, epilepsy, schizophrenia, neurodegenerative diseases, cerebral ischemia and cerebral infarction,Psychosis determined by the increase of amino acids, sidosica dementia, meningitis, tinis, apoplejia, Tourette sindrome, etc