Compounds and methods for the diagnosis and treatment of clinical conditions related to amiloride

摘要

1. It refers to a method for inhibiting the polymerization of amiroides fiber, which contains a quinolinhidrazona compound in a formula, R1, R2, R3, R4, R5 are h, tar, cyclopropyl, arilo, trifluoroethane, halo, or7; R7 is tar, arilo; R6 is benzopyridinol, replaced by H, tar, cyclopropyl, arilo, halo; One or more compound atoms can be selectively substituted by radioactive atoms called 131I, 125I, 123I, 76Br, 75br, 18F, 19F, 15O, 11o, which are 4-methyl-7-methyl-2 - (4-quiollmethyl-enohydralazino) quinolina, 4-ethyl-7-methyl-2 - (4-quiollmethyl-hydrolazino) quinalphylacino priority compounds, 4-ethyl-7-etoxi-2 - (4-quinolililmethylenohyalacin) quinolina et al;It also refers to (I) compounds related to amiloila fiber (I) to provide a precipitate called "precipitate"; (II) compounds composed of an active agent, such as dukemycin, galantamina, taclin, selegilina, fissistigmine, revisagina, donepizil, metrifonato, milamelina, xalomelina, saluzola, acel-l-cardina, idebena, Neuroestrogens, neuroestrogens and compounds can be used as bioanalysis tools to diagnose and treat conditions of amiloride disease, such as Alzheimer's disease, Down's syndrome, diabetes, hemophilia hereditary cerebral hemorrhage, family nephropathy and antioxidants.