BENZOILGUANIDINES ORTO-SUBSTITUTED PROCESS FOR THE PREPARATION OF ITS USE AS A MEDICINAL PRODUCT OR DIAGNOSTIC AGENT AND THE MEDICINAL PRODUCTS CONTAINING THEM

摘要

Ortho-substituted benzoyl-guanidines of formula (I) and their salts are new: R1 = H; F; Cl; Br; I; CN; NO2; 1-8 C alkyl; 1-8 C alkoxy; 3-8 C cycloalkyl; 3-8 C cycloalkoxy; Xa-(CH2)b-(CF2)c-CF3; SR10; OR10; CR10R11R12; Ph, etc.;R2 or R3 = OCOR27 and the other = R1;R4, R5 = H; 1-4C alkyl; 1-4C alkoxy; etc.;X = e.g. O; a = 0 or 1;b = 0-2;c = 0-3;R10 = -CfH2f-Q;Q = e.g. 3-8 C cycloalkyl;f = 0-2; R11, R12 = H; 1-4 C alkyl; or R10; R27 = e.g. 1-8C alkyl.