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NEW COUMARIN HYDROXY AND POLYHYDROXY DERIVATIVES, THEIR PREPARATION AND THEIR ANTIVIRAL ACTION
NEW COUMARIN HYDROXY AND POLYHYDROXY DERIVATIVES, THEIR PREPARATION AND THEIR ANTIVIRAL ACTION
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机译:新香豆素的羟基和多羟基衍生物,其制备及其抗病毒作用
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摘要
The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: CHEM wherein R1 = R2 = 4-hydroxycoumarin; R1 = R2 = 4,7-dihydroxycoumarin; R1 = R2 = 4,5,7-trihydroxycoumarin; R1 = 4-hydroxycoumarin, R2 = -CH(OH)CH3. An object of the invention are also processes for the preparation of hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids, and the antiviral action thereof. Novel hydroxy and polyhydroxy derivatives of coumarin according to the present invention exhibit antiviral action against HIV-1 virus.
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机译:本发明涉及与通式I,II,III和IV的二醛和醛酸稠合的香豆素的新型羟基和多羟基衍生物:其中R 1 = R 2 = 4-羟基香豆素; R 1 = R 2 = 4,7-二羟基香豆素; R 1 = R 2 = 4,5,7-三羟基香豆素; R 1 = 4-羟基香豆素,R 2 = -CH(OH)CH 3。本发明的目的还在于与二醛和醛酸融合的香豆素的羟基和多羟基衍生物的制备方法及其抗病毒作用。根据本发明的香豆素的新型羟基和多羟基衍生物表现出针对HIV-1病毒的抗病毒作用。
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