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Pc10657 / 20136 / BB, a benzoic acid isocyclohexane nitrate derivative as a PDE4 isotope selective inhibitor

机译:PC10657 / 20136 / BB,苯甲酸硝酸异环己烷硝酸酯衍生物,作为PDE4同位素选择性抑制剂

摘要

e. For the treatment of diseases caused by activity and decomposition, especially asthma, chronic bronchitis and chronic lung disease (1.0): see formula, month 0, 1 or 2; n is 1 or 2; wwa-o -.-S (= O) t, where t is 0, 1 or 2, - n (R3 -);This means (c) (RE) - O - [n - (o)]; RA and Rb are - H -, F -, CF3 tar (C1-C6),-Cyclopentyl compounds (C3-C7); phenyl, benzene or alternative isocyclopropyl other substances, substituted by 0 to 3 R10 substitutes; or RA and Rb are considered together as other spirals (1.0.0) forming the formula;However, the condition is that all meanings of PRA and Rb are considered to form the rest of the formula (1.1.0) together;WITH THE CONDITION THAT FOR ALL THE MEANINGS OF RA AND RB, WHEN R10 AS A SUBSTITUTE FOR RA OR RB HAS THE MEANING OF -OR12, -OC (= O) R13 OR -OC (= O) NR12R13, THE POSITIONAL RELATION OF SAID -OR12, -OC (= O) R13, O -OC (= O) NR12R13 FACED A -OR12 AS A MEANING OF Z, NOT A NEIGHBOR; R5 AND R6 ARE CONSIDERED TOGETHER TO FORM A REST OF THE PARTIAL FORMS FROM (1.1.1) TO (1.1.5) SEE FORMS, WHERE R7 AND R8 IN EACH OF SUCH PARTIAL FORMS ARE -H; -CH3, -OCH3; OR THEY ARE ABSENT, IN WHICH CASE THE LINE OF TRACES ---- REPRESENTS A DOUBLE LINK; Q IS PHENYL; PYRROLYL; FURANILO, TIENILO, PIRIDILO; PYRIMIDINYL; IMIDAZOLYL; THIAZOLYL; OXAZOLYL;A REST CYCLOALKYL (C5-C7) MONOCICLICO; A MONOCYCLE REST-CYCLOALQUENYL (C5-C7) THAT IS AN INDEPENDENTLY SELECTED MEMBER OF THE GROUP CONSTITUTED BY CYCLOPENTENE, CYCLOPENTADIENE, CYCLLOHEXENE; 1,3-CYCLLOHEXADIENE; 1,4-CYCLLOHEXADIENE; CYCLLOHEPTENE; 1,3-CYCLLOHEPTADIENE; AND CYCLLOHEPTATRIENE, OR A REST -CYCLOALKYLL (C7-C10) OR -CYCLOALKENYLL (C7-C10) BICYCLE, PREFERABLY ONE WHO IS A SELECTED MEMBER OF THE GROUP 3.2, NORBORNYN, 2 NORBORNYCLE] 1] OCTANYL, BICYCLE [3.3.0] OCTANYL, BICYCLE [2.2.2] OCT-5-ENYL, BICYCLE [2.2.2] OCT-7-ENYL, BICYCLE [3.3.1] NONANYL, AND ADAMANTANYL; Y Z IS -OR12; -C (= O) R12;Or something you can take
机译:e。用于治疗由活动和分解引起的疾病,尤其是哮喘,慢性支气管炎和慢性肺病(1.0):参见配方,第0、1或2个月; n为1或2; wwa-o -.- S(= O)t,其中t是0、1或2,-n(R3-);这意味着(c)(RE)-O-[n-(o)]; RA和Rb为-H-,F-,CF3焦油(C1-C6),环戊基化合物(C3-C7);苯基,苯或其他异环丙基其他物质,被0至3个R10取代基取代;或RA和Rb一起视为构成公式的其他螺旋形(1.0.0);但是,条件是将PRA和Rb的所有含义都认为构成了公式(1.1.0)的其余部分;其条件就RA和RB的所有含义而言,当R10替代RA或RB时,其含义是-OR12,-OC(= O)R13或-OC(= O)NR12R13,即-OR12的位置关系, -OC(= O)R13,O -OC(= O)NR12R13面向A -OR12作为Z的含义,而不是邻域; R5和R6被认为构成了从(1.1.1)到(1.1.5)的其余部分形式的剩余部分,其中每个这样的部分形式的R7和R8都是-H; -CH3,-OCH3;或者,在跟踪线的情况下,它们不存在----代表双链接; Q是苯基;吡咯基;富拉尼洛,蒂涅罗,皮里迪洛;吡MIDI酸;咪唑基;噻唑基;恶唑基;单环烷基(C5-C7)单氰基;单环休息-环戊基(C5-C7),是由环戊烯,环戊二烯,环己烯组成的独立选择的成员; 1,3-环己二烯; 1,4-环己二烯;环庚烯; 1,3-环庚二烯;和环庚三烯,或REST-CYCLOALKYLL(C7-C10)或-CYCLOCLONKYYLLL(C7-C10)自行车,最好是3.2组的选定成员,NORBORNYN,2 NORBORNYCLE] 1] OCTANYL,BICYCLE。辛基,自行车[2.2.2] OCT-5-烯基,自行车[2.2.2] OCT-7-烯基,自行车[3.3.1]壬基,和金刚烷基; Y Z是-OR12; -C(= O)R12;或您可以拿的东西

著录项

  • 公开/公告号SV2002000299A

    专利类型

  • 公开/公告日2002-07-03

    原文格式PDF

  • 申请/专利权人 PFIZER PRODUCTS INC.;

    申请/专利号SV20010000299

  • 发明设计人 MARFAT ANTHONY;CHAMBERS ROBERT JAMES;

    申请日2001-01-31

  • 分类号A61K31/44;

  • 国家 SV

  • 入库时间 2022-08-22 00:43:33

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