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A PROCESS FOR THE PREPARATION OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANE-1-OL AND BIS-((R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANE-1-OL)-1,4-DIAZABICYCLO2.2.2OCTANE
A PROCESS FOR THE PREPARATION OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANE-1-OL AND BIS-((R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANE-1-OL)-1,4-DIAZABICYCLO2.2.2OCTANE
The present invention is concerned with a process for the preparation of (R)-l-(3,5-bis(trifluo-romethyl)phenyl)ethanol by asymmetric transfer hydrogenation of 3,5-bis(trifluoromethyl)acetophenone using a rhodium of ruthenium catalyst and a ligand in the presence of an alcohol. Also claimed are specific complexes of (S, R)-l-amino-2-hydrox-yindane with rhodium and ruthenium as well as a process for purifying (R)-l-(3,5-bis(trifluoromethyl)phenyl)ethanol by means of its complex with l,4-diazabicyclo[2.2.2]octane and the 2:1 complex of (R)-l-(3,5-bis(trifluoromethyl)phenyl)ethanol with 1,4-diazabicyclo[2.2.2]octane.
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