HALOGEN-SUBSTITUTED 4-PHENYL-1-PIPERAZIN, PIPERIDIN AND TETRAHYDROPIRIDINE û DERIVATIVES A PHARMACEUTICAL COMPOSITION BASED THEREON, THEIR APPLICATION FOR PRODUCING MEDICAMENT, AND A METHOD FOR THE TREATMENT OF PSYCHOSIS

摘要

The present invention relates to substituted 4-phenyl-l-piperazinyl derivatives having formula (I), wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is ?? and no bond when W is N or CH; R1 and R2 are independentlyselected from hydrogen and halogen, provided at least one of R1 and R2 is a halogen atom; X is CH2, O, S, CO, CS, SO or SO2; and Q is a group of formula (II) provided that X is not O or S when the group Q is attached via an N atom; and any of its enantiomers and add addition salts thereof. These compounds have high affinity for D4 receptors. (??) (????)