DESTRUCTION OF CONTAMINATING TUMOR CELLS IN STEM CELL TRANSPLANTS WITH BISPECIFIC ANTIBODIES

摘要

Method for reducing the number of tumour cells in a stem cell graft ex vivo comprises contacting the graft with an intact bispecific antibody (a hybrid antibody comprising two different Fab fragments and an Fc fragment) that is (A) capable of binding to receptors on T-cells and other cells bearing Fc receptors and (B) capable of binding to a tumour-associated antigen on the tumour cells.